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Diflucan australia over the counter in form of gel capsules [20] and also over the counter for treatment of milder forms acne [21]. However, the clinical evidence on use of Diflucan for the management acne vulgaris is limited and there are no large, placebo-controlled trials to support its efficacy in acne treatment or management. The efficacy of Diflucan for treatment acne vulgaris is also unproven, and this may be because of the lack evidence on use of Diflucan and/or the absence use of this particular Diflucan in acne treatment. is not available over the counter in Australia. However, Diflucan is available over the counter in New Zealand and Europe as a nonprescription topical antiseptic gel for the treatment of mild acne vulgaris [6, 22]. The only double-blind, placebo-controlled, randomized clinical studies on the use of Diflucan in treatment acne show that patients have significantly better tolerability and fewer side effects after treatment with Diflucan compared to placebo [21, 22]. There is also some evidence that Diflucan is not effective in treating acne vulgaris. one pilot study in patients aged 14–40, the response rates for Diflucan (12.3%) were lower than those for placebo (31%) in people with mild acne [19]. The pilot study was carried out in Germany patients aged 11–29 years. No comparison groups or control were provided in this study. Although it was a small pilot study, there were too few patients studied to draw firm conclusions. In another pilot study by the same authors in Germany and Austria, Diflucan was shown to be more effective than placebo in patients aged 12–29 years [23]. The results in this study were statistically significant. In a prospective study involving 48 patients with mild to moderate acne, the response rate to Diflucan (32.5%) was lower than that to placebo (52.9%) for one of the six months in which these patients were prescribed Diflucan [24]. Diflucan is one of the two main ingredients in a commercial form of Neosutrol [25]. contains 4% Diflucan and is one of the few products on market which specifically states that it has been shown in some studies to have clinical efficacy in the treatment of acne. Although Neosutrol has been shown to be effective in some studies, there have been no large-scale comparative studies of it using Diflucan for the treatment of acne acne. The efficacy of Neosutrol can be seen in other studies where Diflucan has been used. In one study patients aged 15–40 years, the treatment response rate for Neosutrol was 60%, compared with 35% for placebo [26]. In another study involving 18 patients with mild acne treated for two years with Neosutrol and placebo, the treatment response rate for Neosutrol was 53.5% and placebo 43.5% [27]. Neosutrol contains one or two ingredients. The first ingredient, 2% dibutyl sulfate, is derived from SLS or SLS-synthetic polymer which is commercially available. In a double-blind, placebo-controlled study with 50 patients aged 18–40 years in Diflucan 50 Pills 150mg $132 - $2.64 Per pill Korea, the response rate to Neosutrol was 60% and for placebo 33% [28]. In a study involving 35 patients with mild acne treated for one year with Neosutrol and two placebo tablets, the response rate to Neosutrol was 60% in those who received it every night for four weeks and 37% in those who received it every other day. Although the study had a non-comparative design, it demonstrates the efficacy of Neosutrol in treatment acne vulgaris [29]. In patients with mild acne who underwent topical retinoid application for one month, the response rate to Neosutrol was 52% compared with 40% for placebo [30]. The efficacy of Neosutrol in treatment acne was also evident in patients aged 17–34 years who were treated with isotretinoin for three months. The response rate was significantly lower in the Neosutrol group than isotretinoin group, at 38.7% compared with 56.9% [31]. In patients aged 18–34 years who had diflucan otc australia mild acne using isotretinoin for five months, the response rate to Neosutrol was 64% compared with 41.5% in the Neosutrol plus isotretinoin group and in the Neosutrol+ isotretinoin group, which was the combination of Neosutrol plus a retinoid [32].

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